By Denise Mann 

HealthDay Reporter


TUESDAY, March 28, 2023 (HealthDay Information) — When you’re one of many hundreds of thousands of individuals with allergic bronchial asthma or eczema, chances are you’ll be extra more likely to develop the wear-and-tear type of arthritis as you age.

That is the principle discovering from a brand new examine that examined the chance of creating osteoarthritis amongst individuals with the 2 allergic situations.

The examine wasn’t designed to say how, or even when, these allergic illnesses enhance osteoarthritis threat, however the researchers do have a concept.

“Our group has executed work displaying that mast cells [a type of allergic cell] are elevated in numbers within the joints of individuals with osteoarthritis, and their exercise contributes to the event of osteoarthritis,” stated examine writer Dr. Matthew Baker, medical chief within the division of immunology and rheumatology at Stanford College in Stanford, Calif.

And bronchial asthma and eczema will be the tip of the iceberg, he stated.

“It’s doable that different atopic situations resembling seasonal allergy symptoms, meals allergy symptoms and/or allergic rhinitis [hay fever] might present an identical threat,” Baker famous.

These researchers didn’t have a look at these situations within the new examine.

For the examine, they reviewed insurance coverage claims from two databases. The primary set included greater than 117,000 individuals with bronchial asthma or eczema and 1.2 million individuals with out these situations. After eight years of follow-up, the chance of creating osteoarthritis was 58% larger amongst of us with allergic bronchial asthma or eczema than amongst their counterparts with out these allergic situations.

The chance of osteoarthritis was even larger amongst individuals who had each allergic bronchial asthma and eczema, the examine findings confirmed.

About half of individuals with eczema even have allergic situations resembling hay fever, bronchial asthma or meals allergy symptoms, in response to the American Academy of Allergy, Bronchial asthma and Immunology.

The researchers additionally in contrast the chance of creating osteoarthritis amongst individuals with allergic bronchial asthma to these with power obstructive pulmonary illness (COPD), a lung illness that doesn’t contain allergic pathways. Individuals with bronchial asthma had been 83% extra more likely to develop osteoarthritis than these with COPD.

Within the second database, the percentages of creating osteoarthritis had been 42% larger amongst individuals with both allergic bronchial asthma or eczema and 19% larger amongst these with each situations. These findings weren’t as sturdy as these seen within the first set as they took physique mass index (BMI) into consideration. (BMI is a estimate of physique fats based mostly on peak and weight.) A excessive BMI is a threat for creating osteoarthritis.

The million-dollar query is whether or not treating bronchial asthma or eczema lowers arthritis threat. The researchers did not have a look at this on this examine, however there may be cause for hope.

Older analysis has linked using antihistamines with diminished structural development in knee osteoarthritis, Baker stated.

“We’re hopeful that any variety of medication that work to inhibit mast cells or mast cell merchandise [such as histamine] will scale back the incidence of osteoarthritis,” he stated.

The examine — printed March 27 within the Annals of the Rheumatic Illnesses — was funded by the U.S. Nationwide Institutes of Well being.

The connection between osteoarthritis and allergic illnesses may very well be the low-grade irritation, stated Dr. Theodore Fields, a rheumatologist on the Hospital for Particular Surgical procedure in New York Metropolis, who reviewed the findings.

The excellent news is that there are extra therapies for eczema right this moment than ever earlier than and lots of extra are within the pipeline.

“If therapy of atopic illness helps forestall or reduce osteoarthritis, there are a whole lot of choices and will likely be extra,” Fields stated.

“For sufferers with eczema or bronchial asthma, this information could make them conscious that they is likely to be extra more likely to get osteoarthritis,” he stated.

When you’ve got an allergic illness and develop aches and pains in your joints, see your physician, he suggested.

“We have now many methods to enhance the signs of osteoarthritis however do not but have a disease-modifying therapy,” Fields stated.

“There will be some hope on this examine for sufferers with eczema or bronchial asthma that their therapy for atopic illness may forestall or diminish their potential to develop osteoarthritis,” he added.

Extra data

The American Academy of Allergy, Bronchial asthma & Immunology has extra on eczema.



SOURCES: Matthew Baker, MD, medical chief, division of immunology and rheumatology, Stanford College, Stanford, Calif.; Theodore Fields, MD, rheumatologist, Hospital for Particular Surgical procedure, New York Metropolis; Annals of the Rheumatic Illnesses, March 27, 2023

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